Literature summary extracted from

Huang, N.J.; Lin, Y.C.; Lin, C.Y.; Pishesha, N.; Lewis, C.A.; Freinkman, E.; Farquharson, C.; Millan, J.L.; Lodish, H.
Enhanced phosphocholine metabolism is essential for terminal erythropoiesis (2018), Blood, 131, 2955-2966 .

Organism

EC Number	Organism	UniProt	Comment	Textmining
3.1.3.75	Homo sapiens	Q8TCT1	-	-
3.1.3.75	Mus musculus	Q8R2H9	-	-

Source Tissue

EC Number	Source Tissue	Comment	Organism	Textmining
3.1.3.75	erythrocyte	-	Homo sapiens	-
3.1.3.75	erythrocyte	-	Mus musculus	-

General Information

EC Number	General Information	Comment	Organism
3.1.3.75	physiological function	transcription of PHOSPHO1 is strongly upregulated during the terminal stages of erythropoiesis, concomitant with increased catabolism of phosphatidylcholine and phosphocholine. Depletion of PHOSPHO1 impairs differentiation of fetal erythroblasts	Homo sapiens
3.1.3.75	physiological function	transcription of PHOSPHO1 is strongly upregulated during the terminal stages of erythropoiesis, concomitant with increased catabolism of phosphatidylcholine and phosphocholine. Depletion of PHOSPHO1 impairs differentiation of fetal erythroblasts, and in adult mice depletion impairs phenylhydrazine-induced stress erythropoiesis. Loss of PHOSPHO1 also impairs phosphocholine catabolism in mouse fetal liver progenitors and results in accumulation of several lipids, and ATP production is reduced as a result of decreased oxidative phosphorylation. Glycolysis replaces oxidative phosphorylation in PHOSPHO1 knockout erythroblasts and the increased glycolysis is used for the production of serine or glycine	Mus musculus

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Release 2023.1 (January 2023)